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No specific dose adjustment suggested when tofacitinib coadministered with powerful CYP2C19 inhibitors; lessen tofacitinib dose if coadministered with both of those average CYP3A4 and powerful CYP2C19 inhibitors .iloperidone raises levels of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Iloperidone i